Volume-1, Issue-1

RP-HPLC Method Development and Validation for the Simultaneous Estimation of Etodolac and Paracetamol in Tablet Dosage Form

Tabassum*, K.Pranitha, J.Priya, Rama Thilagam

Department of Pharmaceutical Analysis, Smt.Sarojini Ramulamma College of Pharmacy,Mahabubnagar(509001) , A.P. INDIA

A simple reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated for simultaneous determination of Etodolac And Paracetamol in pharmaceutical tablet dosage form. Chromatographic analysis was performed on a Symmetry X-terra C8 (4.6mm x 150mm, 5μm)column at ambient temperature with a mixture of mixed ortho phosphoric acid buffer and Acetonitrile in the ratio 50:50 v/v (ortho phosphoric acid buffer preparation; Take 1000ml of HPLC grade water. Dissolve 2.72 grams of Potassium di hydrogen phosphate salt and Adjusted the pH to 3.0 with orthophosphoric acid. as mobile phase, at a flow rate of 0.9 mL min-1. UV detection was performed at 260 nm. The method was validated for accuracy, precision, linearity and sensitivity. The retention times of Etodolac And Paracetamol were 2.190 and 3.373 min, respectively.

Formulation and evaluation of gastroretentive mucoadhesive bilayer tablets of losartan potassium

Manohar Reddy Sagili*, Dr. V. Uma Maheswara Rao, Vijaya Vani CH.S, Pratyusha A

Department of Pharmaceutics, CMR College of Pharmacy, Hyderabad (501401), A.P, India

The objective of the present study was to develop and evaluate gastro retentive mucoadhesive bilayered tablets of losartan potassium. Bilayered tablets were prepared by direct compression method by using crosscarmellose sodium (CCS) and sodium starch glycolate (SSG) in different strengths (4%, 5% and 6% w/w) for immediate release (loading dose). The IR formulation containing CCS (6% w/w) showed better drug release. Mucoadhesive materials such as sodium alginate, guar gum and xanthan gum (natural gums) in different strengths (15%, 25%, and 35% w/w) were used for controlled release (maintenance dose) layer. FTIR studies revealed that there was no interaction between the drug and excipients used in the study.

Development and In Vitro Evaluation of Fast Dissolving Tablets of Losartan Potassium

Dr. Hindustan Abdul Ahad*, Sreekanth K, Sukanya V, Bhanubee C, Taj Khan H

Department of Pharmaceutics, Balaji College of Pharmacy, Anantapur, AP, India

In the present research work an attempt has been made to develop mouth dissolving tablets of Losartan Potassium by including clove oil as flavor and local anesthetic agent on taste buds. The tablets were prepared by direct compression technique. The formulated tablets were evaluated for preformulation and post formulation parameters and they were found to be satisfactory. The formulated mouth dissolving tablets possessed good drug releasing property, good mouth feel and improved drug availability with better patient compliance.

Pharmacognostical and Phytochemical Screening of Sesbania grandiflora

* Chandra Shekar A, **Mastanaiah P

*MD, Pharma Mentors
**BDM, Dr Vet Pharma

 A perusal of the literature reveals that the following uses have been reported from the various parts of the plant, they are laxative, diuretic, emetic, emmenagogue, febrifuge and tonic, agati is a folk remedy for bruises, catarrh, dysentery, eyes, fevers, headaches, smallpox, sores, sore throat, and stomatitis (Duke and Wain, 1981). Bark, leaves, gums and flowers are considered medicinal. The astringent bark was used in treating smallpox and other eruptive fevers. The juice from the flowers is used to treat headache, head congestion, or stuffy nose. As a snuff, the juice is supposed to clear the nasal sinuses.

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