International Journal for Advanced Review and Research in Pharmacy (IJARRP)
ISSN: 2349-1329

Current Issue- Volume: 2 Issue: 1

Formulation and Development of Vancomycin hydrochloride for injection

Venkateswarlu Kudupudi *   , Kusuma D   ,     ,     ,    
Status:  Published
The aim of present study is to formulate an intravenous injection of Vancomycin Hydrochloride. It was belongs to the category of antibiotic and it was widely used in staphylococcal endocarditis. The main objective of the study was to develop rapid reconstituted formulation of Vancomycin Hydrochloride by using lyophilization technology. The lyophilization was carried in different batches of the Vancomycin Hydrochloride were prepared with varying the excipients and its concentration while keeping the lyophilization cycle constant. An optimized lyophilization cycle of 36 hours was achieved. The optimized lyophilized product was subjected to in vitro parameters such as cake appearance, reconstitution time, PH, assay, RS, particulate matter, water content, IR, color value, % light transmittance, DSC. After considering all product characteristics batch-6 was considered as an optimized formulation.

Formulation and Evaluation of Oral Disintegrating tablets of Zolmitriptan

Venkateswarlu Kudupudi *   , Kusuma D   ,     ,     ,    
Status:  Published
Zolmitriptan is widely used as Anti migraine agent. They are formulated as oral disintegrating tablets which show better patient acceptability and compliance with improved efficacy when compared with conventional dosage forms. Based on various studies carried out we have arrived at the following conclusions: Direct compression was used for the preparation of oral disintegrating tablets of Zolmitriptan Based on the preliminary studies various formulation trials (F1-F9) were carried out with different concentrations of superdisintegrants and diluents.

Anti-Dengue and Safety Study of Novel Herbal Formulation- DENPAP? a Liquid Dosage Form

Dr. Kotrappa Yankappa Mathur *   , Dr. Maria Carina Cordeiro   , Sreedhar Pendyala   ,     ,    
Status:  Published
Dengue is a viral vector borne disease that has become a serious health problem worldwide and no treatment or vaccine is available for its prevention. The aim of the study was to evaluate the efficacy and safety of a novel herbal liquid formulation ?DENPAP??. The toxicity study was performed to evaluate the oral acute toxicity of DENPAP? in Wistar rats as per OECD 425 guidelines: up and down procedure method. The efficacy study was carried out to identify the efficacious dose of DENPAP? for Anti-Thrombocytopenic effect in Chemical (Cylcophosphamide) induced Thrombocytopenia model in Sprague Dawley rats for a period of 14 days. The acute toxicity study was carried out in Wistar Albino rats at different doses for a period of 14 days and it was concluded that the LD50 value for DENPAP? was more than 2000 mg/kg.

A Review on Anti-Urolithiatic Herbs in Siddha Medicine

Samraj Kudupudi *   , Parthibhan P   , Kanakavalli K   , Natarajan T   , Porchelvan P  
Status:  Published
Urolithiasis is the condition where urinary stones are formed or located anywhere in the urinary system. Urolithiasis is the third most common disorder of urinary tract found in humans and its incidence is quite high all over the world. Urinary calculi are formed by deposits of polycrystalline aggregates composed of varied amount of crystalloid and organic matrix. It is clinically manifested by dysuria, burning and painful micturition, pain in the pelvis and lumbo sacral region and the presence of small stones in the urine. It is estimated that at least 10% of the population in the industrialized part of the world is afflicted by urinary tract stone disease. In Siddha system of Medicine, there are many herbs which are used to prevent the recurrence of the stone formation.

Role of Protein-Restricted diet supplemented with Ketoanalogue in Dialysis Patients

Sunilkanth V *   ,     ,     ,     ,    
Status:  Published
Dialysis patient lose protein during dialysis along with inability of the body to use and process amino acids due to kidney disease leading to requirement of higher protein demand than the average healthy adult. In the pre-dialysis and dialysis period the dietary approach in the different phases of chronic renal insufficiency (CRI) has been highly controversial. Lack of protein in dialysis patient will result in the development of PEM, increased mortality and decreased physical functioning and quality of life

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